Empowering HIV-1 genotyping drug resistance monitoring: Sample to report

Short TAT and automation friendly

Fast image

Work for low frequency drug resistance

Covering the main drug-resistant regions

Various analysis functions

Empowering HIV-1 genotyping drug resistance monitoring: Sample to report

Short TAT and automation friendly

Fast image

Work for low frequency drug resistance

Covering the main drug-resistant regions

Various analysis functions

Empowering HIV-1 genotyping drug resistance monitoring: Sample to report

Short TAT and automation friendly

Fast image

Work for low frequency drug resistance

Covering the main drug-resistant regions

Various analysis functions

Empowering HIV-1 genotyping drug resistance monitoring: Sample to report

Short TAT and automation friendly

Fast image

Work for low frequency drug resistance

Covering the main drug-resistant regions

Various analysis functions

Comprehensive, sensitive and accurate HIV-1 genotyping and DRM detection

HIV drug resistance poses a significant global challenge to the sustainability of antiretroviral therapy and is the most common cause of antiviral treatment failure in HIV patients. Next Generation Sequencing holds significant promise in providing scalable throughput, increased sensitivity and accuracy for detecting drug resistance mutations.

MGI has developed an HIV-1 drug resistance sample to report workflow to accurately characterize HIV drug resistance in both plasma and culture specimens. Based on deep sequencing, capable of detecting drug resistance with low-frequency mutation, and combined with MGI’s automated

Sample Prep systems and HIV-GenomePro software, provides users with a streamlined tool for enabling rapid and accurate detection of HIV-1, drug resistance analysis, genome assembly, mutation detection, and evolutionary tracing.

MGI’s HIV -1 genotyping and drug resistance detection package can be deployed as a comprehensive and scalable solution, with the potential to improve individual patient care, as well as contributing to the ongoing research and genomic surveillance critical for the development of effective public health strategies in the fight against HIVDR and Antimicrobial Resistance.

HIV-1 Drug Resistance Sequencing workflow

Library Preparation

~7.5h

MGISP-960/MGISP-100
ATOPlex HIV-1 Amplifications Kit
MGIEasy Fast PCR-FREE FS DNA Library Prep Set
MGISP-100 Automation Machine from MGI-Tech
MGISP-100

Sequencing

~12-40h

High-throughput Sequencing Set
DNBSEQ-G99 SM FCL PE150
DNBSEQ-E25 FCL PE150
MGISP-100 Automation Machine from MGI-Tech
A picture of the DNBSEQ-G99 Sequencer from MGI-Tech

Analysis

~1-2h

HIV-GenomePro Software
HIV-GenomePro Platform

HIV-GenomePro Software
HIV-GenomePro Platform

Precisely analyze and annotate drug resistance and explore with HIV-GenomePro Software

Features

Genotype/subtype annotation
Genotype/subtype annotation
Data quality control
Coverage statistics
PR-RT-IN gene assembly
Virus evolution tracing analysis
SNP and InDel detection
PR-RT-IN gene drug resistance annotation based on Stanford University HIVDB database
Localization of HIV-TRACE for molecular network analysis
Data quality control
Determine if virus concentration reaches threshold
Genomic analysis
Genome assembly
Multiple sequence
alignment of HIV
reference genome
Phylogenetic
tree calculation
Output:
1. Consistent sequence
2. Typing results
Reference
genome alignment
SNP Calling
Mutation drug
Resistance
annotation
Output:
1. SNP locus
2.Evolutionary analysis results
Summarize results and generate report

Next-generation HIV-1 Drug Resistance workflow with DNBSEQ-G99/E25

An ideal tool for HIV drug resistance monitoring and epidemiological research

Library Preparation

Sequencing

Data Analysis

ATOPlex HIV-1 Library Preparation Set

Provides fast, flexible and automatable library preparation workflow, enabling complete libraries in 7.5 hours.

Combined with the MGISP-100, MGISP-960 automated platforms can achieve automated preparation of libraries seamlessly.

MGISP-100 Automation Machine from MGI-Tech

Next-generation HIV-1 Drug Resistance workflow with DNBSEQ-G99/E25

An ideal tool for HIV drug resistance monitoring and epidemiological research

Library Preparation

Sequencing

Data Analysis

ATOPlex HIV-1 Library Preparation Set

Provides fast, flexible and automatable library preparation workflow, enabling complete libraries in 7.5 hours.

Combined with the MGISP-100, MGISP-960 automated platforms can achieve automated preparation of libraries seamlessly.

MGISP-100 Automation Machine from MGI-Tech

Next-generation HIV-1 Drug Resistance workflow with DNBSEQ-G99/E25

An ideal tool for HIV drug resistance monitoring and epidemiological research

Library Preparation

Sequencing

Data Analysis

ATOPlex HIV-1 Library Preparation Set

Provides fast, flexible and automatable library preparation workflow, enabling complete libraries in 7.5 hours.

Combined with the MGISP-100, MGISP-960 automated platforms can achieve automated preparation of libraries seamlessly.

MGISP-100 Automation Machine from MGI-Tech

Precision and Performance With DNBSEQ-G99 & DNBSEQ-E25

DNBSEQ-G99

DNBSEQ-E25

Samples per run icon
Samples per run

≤16 sample /FC

MGI Flow cells icon
Flow Cells

1

Read Lengths

FCL PE150

Nucleic Acid to report

28.5h

DNBSEQ-G99

DNBSEQ-E25

Samples per run icon
Samples per run

≤60 samples /FC

MGI Flow cells icon
Flow Cells

2

Read Lengths

FCL PE150

Nucleic Acid to report

24h

DNBSEQ-G99

DNBSEQ-E25

Samples per run icon
Samples per run

≤16 sample /FC

MGI Flow cells icon
Flow Cells

1

Read Lengths

FCL PE150

Nucleic Acid to report

28.5h

Certification

ISO 13485

Medical Device Quality Management System

ISO 14001

Environmental Management System

ISO 27001

Information Security Management System

Certification

ISO 13485

Medical Device Quality Management System

ISO 14001

Environmental Management System

ISO 27001

Information Security Management System

Certification

ISO 13485

Medical Device Quality Management System

ISO 14001

Environmental Management System

ISO 27001

Information Security Management System

Certification

ISO 13485

Medical Device Quality Management System

ISO 14001

Environmental Management System

ISO 27001

Information Security Management System

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*For Research Use Only

Not for use in diagnostic procedures (except as specifically noted).

Copyright © 2024 MGI tech GmbH, Ltd. All Rights Reserved.

Join our newsletter to stay up to date on features and releases.

I have read and understood MGI’s Privacy Policy, and I consent to the collection and processing of my personal data for handling, responding to my contact, receiving your newsletter as well as promotion and marketing activities.

*For Research Use Only

Not for use in diagnostic procedures (except as specifically noted).

Copyright © 2024 MGI tech GmbH, Ltd. All Rights Reserved.

Join our newsletter to stay up to date on features and releases.

I have read and understood MGI’s Privacy Policy, and I consent to the collection and processing of my personal data for handling, responding to my contact, receiving your newsletter as well as promotion and marketing activities.

*For Research Use Only

Not for use in diagnostic procedures (except as specifically noted).

Copyright © 2024 MGI tech GmbH, Ltd. All Rights Reserved.