Run Time
mIF: 4-5 h (6-plex) / Sequencing: 31 h (FCS, PE150)
Throughput
mIF: 20 Sections/Week (SS, SL) / Sequencing: 55-180 Gb (FCS)
Sample Type
Compatible with FFPE and Frozen Sections/DNA/RNA
DNBSEQ-G400RS FluoXpert
Experience Revolutionary Multi-Omics Research
DNBSEQ-G400RS FluoXpert represents a significant advancement in pathological tissue analysis, integrating cutting-edge multiplex immunofluorescence (mIF) staining, imaging, and sequencing technologies. Designed to overcome the limitations of traditional Hematoxylin-Eosin (H&E) and immunohistochemistry (IHC) staining methods, FluoXpert enables quantitative and qualitative analysis on a single tissue section without necessitating multiple sections, thus conserving precious sample material.
DNBSEQ-G400RS FluoXpert 's mIF technology allows for the simultaneous detection of multiple protein targets, preserving spatial information and tissue integrity. This capability is crucial for studying the cellular composition, functional phenotype, and intercellular interactions within target tissues, offering new insights into the tumor microenvironment (TME) and immune system interactions.
Specifications
Explore the core capabilities and technical details.
Applications
Whole-Genome
Whole-Genome
Gene Expression
Metagenomics
Population Studies
Transcriptome
Methylation Analysis
Multiomics
Your Data Security is Our Top Priority
All our sequencing platforms can work as standalone systems from sample to result without any network connection, eliminating the risk of data breaches and ensuring complete data security.
The
DNBSEQ-G400RS FluoXpert
Advantage
Comprehensive Compatibility and Flexibility
Supports fresh frozen and FFPE samples with commercially available antibodies. Detect 3-24 markers per tissue section, cutting reagent usage by up to 5 times.
High-Resolution Imaging and Automation
Provides subcellular resolution with optimized algorithms. Automates staining and imaging, ensuring consistent, high-quality results.
Comprehensive Data Collection and Analysis
Combines histomorphological and molecular data, including spatial protein marker detection and gene sequencing. Advanced tools enhance accuracy and research depth.
Automated Staining and Imaging
Simplify workflows with automated processes, detecting multiple biomarkers while preserving spatial data
Comprehensive Compatibility and Flexibility
Supports fresh frozen and FFPE samples with commercially available antibodies. Detect 3-24 markers per tissue section, cutting reagent usage by up to 5 times.
High-Resolution Imaging and Automation
Provides subcellular resolution with optimized algorithms. Automates staining and imaging, ensuring consistent, high-quality results.
Comprehensive Data Collection and Analysis
Combines histomorphological and molecular data, including spatial protein marker detection and gene sequencing. Advanced tools enhance accuracy and research depth.
Automated Staining and Imaging
Simplify workflows with automated processes, detecting multiple biomarkers while preserving spatial data
Comprehensive Compatibility and Flexibility
Supports fresh frozen and FFPE samples with commercially available antibodies. Detect 3-24 markers per tissue section, cutting reagent usage by up to 5 times.
High-Resolution Imaging and Automation
Provides subcellular resolution with optimized algorithms. Automates staining and imaging, ensuring consistent, high-quality results.
Comprehensive Data Collection and Analysis
Combines histomorphological and molecular data, including spatial protein marker detection and gene sequencing. Advanced tools enhance accuracy and research depth.
Automated Staining and Imaging
Simplify workflows with automated processes, detecting multiple biomarkers while preserving spatial data
Comprehensive Compatibility and Flexibility
Supports fresh frozen and FFPE samples with commercially available antibodies. Detect 3-24 markers per tissue section, cutting reagent usage by up to 5 times.
High-Resolution Imaging and Automation
Provides subcellular resolution with optimized algorithms. Automates staining and imaging, ensuring consistent, high-quality results.
Comprehensive Data Collection and Analysis
Combines histomorphological and molecular data, including spatial protein marker detection and gene sequencing. Advanced tools enhance accuracy and research depth.
Automated Staining and Imaging
Simplify workflows with automated processes, detecting multiple biomarkers while preserving spatial data
Run Time
mIF: 4-5 h (6-plex) / Sequencing: 31 h (FCS, PE150)
Throughput
mIF: 20 Sections/Week (SS, SL) / Sequencing: 55-180 Gb (FCS)
Sample Type
Compatible with FFPE and Frozen Sections/DNA/RNA
DNBSEQ-G400RS FluoXpert
Experience Revolutionary Multi-Omics Research
DNBSEQ-G400RS FluoXpert represents a significant advancement in pathological tissue analysis, integrating cutting-edge multiplex immunofluorescence (mIF) staining, imaging, and sequencing technologies. Designed to overcome the limitations of traditional Hematoxylin-Eosin (H&E) and immunohistochemistry (IHC) staining methods, FluoXpert enables quantitative and qualitative analysis on a single tissue section without necessitating multiple sections, thus conserving precious sample material.
DNBSEQ-G400RS FluoXpert 's mIF technology allows for the simultaneous detection of multiple protein targets, preserving spatial information and tissue integrity. This capability is crucial for studying the cellular composition, functional phenotype, and intercellular interactions within target tissues, offering new insights into the tumor microenvironment (TME) and immune system interactions.
Specifications
Explore the core capabilities and technical details.
Applications
Whole-Genome
Whole-Genome
Gene Expression
Metagenomics
Population Studies
Transcriptome
Methylation Analysis
Multiomics
Your Data Security is Our Top Priority
All our sequencing platforms can work as standalone systems from sample to result without any network connection, eliminating the risk of data breaches and ensuring complete data security.
The
DNBSEQ-G400RS FluoXpert
Advantage
Comprehensive Compatibility and Flexibility
Supports fresh frozen and FFPE samples with commercially available antibodies. Detect 3-24 markers per tissue section, cutting reagent usage by up to 5 times.
High-Resolution Imaging and Automation
Provides subcellular resolution with optimized algorithms. Automates staining and imaging, ensuring consistent, high-quality results.
Comprehensive Data Collection and Analysis
Combines histomorphological and molecular data, including spatial protein marker detection and gene sequencing. Advanced tools enhance accuracy and research depth.
Automated Staining and Imaging
Simplify workflows with automated processes, detecting multiple biomarkers while preserving spatial data
Comprehensive Compatibility and Flexibility
Supports fresh frozen and FFPE samples with commercially available antibodies. Detect 3-24 markers per tissue section, cutting reagent usage by up to 5 times.
High-Resolution Imaging and Automation
Provides subcellular resolution with optimized algorithms. Automates staining and imaging, ensuring consistent, high-quality results.
Comprehensive Data Collection and Analysis
Combines histomorphological and molecular data, including spatial protein marker detection and gene sequencing. Advanced tools enhance accuracy and research depth.
Automated Staining and Imaging
Simplify workflows with automated processes, detecting multiple biomarkers while preserving spatial data
Comprehensive Compatibility and Flexibility
Supports fresh frozen and FFPE samples with commercially available antibodies. Detect 3-24 markers per tissue section, cutting reagent usage by up to 5 times.
High-Resolution Imaging and Automation
Provides subcellular resolution with optimized algorithms. Automates staining and imaging, ensuring consistent, high-quality results.
Comprehensive Data Collection and Analysis
Combines histomorphological and molecular data, including spatial protein marker detection and gene sequencing. Advanced tools enhance accuracy and research depth.
Automated Staining and Imaging
Simplify workflows with automated processes, detecting multiple biomarkers while preserving spatial data
Comprehensive Compatibility and Flexibility
Supports fresh frozen and FFPE samples with commercially available antibodies. Detect 3-24 markers per tissue section, cutting reagent usage by up to 5 times.
High-Resolution Imaging and Automation
Provides subcellular resolution with optimized algorithms. Automates staining and imaging, ensuring consistent, high-quality results.
Comprehensive Data Collection and Analysis
Combines histomorphological and molecular data, including spatial protein marker detection and gene sequencing. Advanced tools enhance accuracy and research depth.
Automated Staining and Imaging
Simplify workflows with automated processes, detecting multiple biomarkers while preserving spatial data
Run Time
mIF: 4-5 h (6-plex) / Sequencing: 31 h (FCS, PE150)
Throughput
mIF: 20 Sections/Week (SS, SL) / Sequencing: 55-180 Gb (FCS)
Sample Type
Compatible with FFPE and Frozen Sections/DNA/RNA
DNBSEQ-G400RS FluoXpert
Experience Revolutionary Multi-Omics Research
DNBSEQ-G400RS FluoXpert represents a significant advancement in pathological tissue analysis, integrating cutting-edge multiplex immunofluorescence (mIF) staining, imaging, and sequencing technologies. Designed to overcome the limitations of traditional Hematoxylin-Eosin (H&E) and immunohistochemistry (IHC) staining methods, FluoXpert enables quantitative and qualitative analysis on a single tissue section without necessitating multiple sections, thus conserving precious sample material.
DNBSEQ-G400RS FluoXpert 's mIF technology allows for the simultaneous detection of multiple protein targets, preserving spatial information and tissue integrity. This capability is crucial for studying the cellular composition, functional phenotype, and intercellular interactions within target tissues, offering new insights into the tumor microenvironment (TME) and immune system interactions.
Specifications
Explore the core capabilities and technical details.
Applications
Whole-Genome
Whole-Genome
Gene Expression
Metagenomics
Population Studies
Transcriptome
Methylation Analysis
Multiomics
Your Data Security is Our Top Priority
All our sequencing platforms can work as standalone systems from sample to result without any network connection, eliminating the risk of data breaches and ensuring complete data security.
The
DNBSEQ-G400RS FluoXpert
Advantage
Comprehensive Compatibility and Flexibility
Supports fresh frozen and FFPE samples with commercially available antibodies. Detect 3-24 markers per tissue section, cutting reagent usage by up to 5 times.
High-Resolution Imaging and Automation
Provides subcellular resolution with optimized algorithms. Automates staining and imaging, ensuring consistent, high-quality results.
Comprehensive Data Collection and Analysis
Combines histomorphological and molecular data, including spatial protein marker detection and gene sequencing. Advanced tools enhance accuracy and research depth.
Automated Staining and Imaging
Simplify workflows with automated processes, detecting multiple biomarkers while preserving spatial data
Comprehensive Compatibility and Flexibility
Supports fresh frozen and FFPE samples with commercially available antibodies. Detect 3-24 markers per tissue section, cutting reagent usage by up to 5 times.
High-Resolution Imaging and Automation
Provides subcellular resolution with optimized algorithms. Automates staining and imaging, ensuring consistent, high-quality results.
Comprehensive Data Collection and Analysis
Combines histomorphological and molecular data, including spatial protein marker detection and gene sequencing. Advanced tools enhance accuracy and research depth.
Automated Staining and Imaging
Simplify workflows with automated processes, detecting multiple biomarkers while preserving spatial data
Comprehensive Compatibility and Flexibility
Supports fresh frozen and FFPE samples with commercially available antibodies. Detect 3-24 markers per tissue section, cutting reagent usage by up to 5 times.
High-Resolution Imaging and Automation
Provides subcellular resolution with optimized algorithms. Automates staining and imaging, ensuring consistent, high-quality results.
Comprehensive Data Collection and Analysis
Combines histomorphological and molecular data, including spatial protein marker detection and gene sequencing. Advanced tools enhance accuracy and research depth.
Automated Staining and Imaging
Simplify workflows with automated processes, detecting multiple biomarkers while preserving spatial data
Comprehensive Compatibility and Flexibility
Supports fresh frozen and FFPE samples with commercially available antibodies. Detect 3-24 markers per tissue section, cutting reagent usage by up to 5 times.
High-Resolution Imaging and Automation
Provides subcellular resolution with optimized algorithms. Automates staining and imaging, ensuring consistent, high-quality results.
Comprehensive Data Collection and Analysis
Combines histomorphological and molecular data, including spatial protein marker detection and gene sequencing. Advanced tools enhance accuracy and research depth.
Automated Staining and Imaging
Simplify workflows with automated processes, detecting multiple biomarkers while preserving spatial data
Integrated Multiplex Immunofluorescence (mIF) Technology
The DNBSEQ-G400RS FluoXpert utilizes advanced multiplex immunofluorescence (mIF) technology, enabling the detection of multiple target proteins within the same tissue section while preserving essential spatial information. This method allows for the comprehensive analysis of complex cellular compositions, functional phenotypes, and intercellular interactions, making it particularly advantageous for studying tumor microenvironments.
Unlike traditional immunohistochemistry (IHC), which requires multiple sections to examine different proteins, mIF can target several proteins in a single section, minimizing sample waste and maintaining tissue integrity. The integrated imaging system features a sophisticated optical setup and a high-resolution stitching algorithm, providing detailed and accurate imaging throughout cycles of staining and elution. This facilitates repeated analysis with minimal tissue damage.
High-throughput Sequencing Integration
The DNBSEQ-G400RS FluoXpert uniquely combines high-throughput genetic sequencing with multiplex immunofluorescence (mIF) staining capabilities, providing a comprehensive platform for simultaneous molecular and morphological analysis. This integration allows researchers to switch between sequencing and staining modes seamlessly, enhancing the device's utility in translational medicine research.
The sequencer's architecture supports various read lengths and throughput options, catering to diverse research needs and scales. Moreover, this dual functionality enables more efficient use of samples and reagents, reduces the operational footprint by eliminating the need for multiple devices, and accelerates multi-omics research by providing both proteomic and genomic data from the same sample.
Experimental Results
DNBSEQ-G400RS FluoXpert comes with a multiplex immunofluorescence reagent set. It is compatible with both frozen tissue and FFPE samples. It is also compatible with commercially available antibodies without a complex conjugation process. The results generated by FluoXpert showed no significant difference from the gold standard, IHC. It can be used in different fields of proteomics research
No significance is observed between mIF and the gold standard IHC
Mouse brain-FFPE section
Mouse brain-frozen sample
Lung adenocarcinoma-
FFPE section
Tonsil FFPE section
Comparison of FluoXpert and IHC staining result
Comparison of FluoXpert and IHC staining result
PanCK
PanCK/Nucleus
CD8
CD8/Nucleus
CD3
CD3/Nucleus
CD68
CD68/Nucleus
Resources
Product Brochure & Manuals
Product Brochure
Resources
Product Brochure & Manuals
Product Brochure
Resources
Product Brochure & Manuals
Product Brochure
Frequently asked questions about the DNBSEQ-G400RS FluoXpert
What is DNBSEQ-G400RS FluoXpert?
What is DNBSEQ-G400RS FluoXpert?
What is DNBSEQ-G400RS FluoXpert?
What are the advantages of the multiplex immunofluorescence function of DNBSEQ-G400RS FluoXpert?
What are the advantages of the multiplex immunofluorescence function of DNBSEQ-G400RS FluoXpert?
What are the advantages of the multiplex immunofluorescence function of DNBSEQ-G400RS FluoXpert?
What are the advantages of the gene sequencing function of DNBSEQ-G400RS FluoXpert?
What are the advantages of the gene sequencing function of DNBSEQ-G400RS FluoXpert?
What are the advantages of the gene sequencing function of DNBSEQ-G400RS FluoXpert?
What are the advantages of DNBSEQ-G400RS FluoXpert dual application?
What are the advantages of DNBSEQ-G400RS FluoXpert dual application?
What are the advantages of DNBSEQ-G400RS FluoXpert dual application?
What is the product composition of DNBSEQ-G400RS FluoXpert?
What is the product composition of DNBSEQ-G400RS FluoXpert?
What is the product composition of DNBSEQ-G400RS FluoXpert?
What is the staining throughput of DNBSEQ-G400RS FluoXpert?
What is the staining throughput of DNBSEQ-G400RS FluoXpert?
What is the staining throughput of DNBSEQ-G400RS FluoXpert?
How are the number of staining rounds and the best throughput of DNBSEQ-G400RS FluoXpert calculated?
How are the number of staining rounds and the best throughput of DNBSEQ-G400RS FluoXpert calculated?
How are the number of staining rounds and the best throughput of DNBSEQ-G400RS FluoXpert calculated?
How to choose DNBSEQ-G400RS FluoXpert image analysis platform?
How to choose DNBSEQ-G400RS FluoXpert image analysis platform?
How to choose DNBSEQ-G400RS FluoXpert image analysis platform?
How to choose FluoXpert mIF set (6-plex standard version)?
How to choose FluoXpert mIF set (6-plex standard version)?
How to choose FluoXpert mIF set (6-plex standard version)?
How to choose FluoXpert multiplex immunofluorescence reagent kit (24-plex custom version)?
How to choose FluoXpert multiplex immunofluorescence reagent kit (24-plex custom version)?
How to choose FluoXpert multiplex immunofluorescence reagent kit (24-plex custom version)?
What changes in the number of stained samples and procedures for the 3-24 plex customized reagent box?
What changes in the number of stained samples and procedures for the 3-24 plex customized reagent box?
What changes in the number of stained samples and procedures for the 3-24 plex customized reagent box?
Does DNBSEQ-G400RS FluoXpert have a plan for applying for IVD qualifications?
Does DNBSEQ-G400RS FluoXpert have a plan for applying for IVD qualifications?
Does DNBSEQ-G400RS FluoXpert have a plan for applying for IVD qualifications?
What is the principle behind FluoXpert?
What is the principle behind FluoXpert?
What is the principle behind FluoXpert?
What are the technical advantages of FluoXpert?
What are the technical advantages of FluoXpert?
What are the technical advantages of FluoXpert?
What is the difference between FluoXpert multiplex immunofluorescence, traditional immunohistochemistry (IHC) and multiplex immunohistochemistry (mIHC)?
What is the difference between FluoXpert multiplex immunofluorescence, traditional immunohistochemistry (IHC) and multiplex immunohistochemistry (mIHC)?
What is the difference between FluoXpert multiplex immunofluorescence, traditional immunohistochemistry (IHC) and multiplex immunohistochemistry (mIHC)?
How to switch between sequencing and immunofluorescence modes?
How to switch between sequencing and immunofluorescence modes?
How to switch between sequencing and immunofluorescence modes?
What is the approximate thickness required for the tissue section?
What is the approximate thickness required for the tissue section?
What is the approximate thickness required for the tissue section?
What is the effective scanning area of the staining carrier?
What is the effective scanning area of the staining carrier?
What is the effective scanning area of the staining carrier?
What is the composition of the FluoXpert staining Flow Cell and how to load it?
What is the composition of the FluoXpert staining Flow Cell and how to load it?
What is the composition of the FluoXpert staining Flow Cell and how to load it?
What is the result format generated from FluoXpert?
What is the result format generated from FluoXpert?
What is the result format generated from FluoXpert?
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*For Research Use Only
Not for use in diagnostic procedures (except as specifically noted).
Join our newsletter to stay up to date on features and releases.
I have read and understood MGI’s Privacy Policy, and I consent to the collection and processing of my personal data for handling, responding to my contact, receiving your newsletter as well as promotion and marketing activities.
*For Research Use Only
Not for use in diagnostic procedures (except as specifically noted).
Join our newsletter to stay up to date on features and releases.
I have read and understood MGI’s Privacy Policy, and I consent to the collection and processing of my personal data for handling, responding to my contact, receiving your newsletter as well as promotion and marketing activities.
*For Research Use Only
Not for use in diagnostic procedures (except as specifically noted).