A picture of the DNBSEQ-G400 Sequencer from MGI-Tech
A picture of the DNBSEQ-G400 Sequencer from MGI-Tech
A picture of the DNBSEQ-G400 Sequencer from MGI-Tech
A picture of the DNBSEQ-G400 Sequencer from MGI-Tech
DNBSEQ-G400 Flow cell

DNBSEQ-G400

Your Day-to-Day Sequencing Solution

CE-IVD

RUO

DNBSEQ-G400 is a versatile benchtop sequencer designed for medium to large genomics projects. Supporting multiple read lengths and sequencing modes, it offers high throughput, accuracy, and flexibility for applications including cancer detection, transcriptomics, and whole genome sequencing. Based on MGI's proprietary DNBSEQ™ Technology, DNBSEQ-G400 supports multi-sequencing modes with increased accuracy, decreased duplicates and reduced index hopping.

Redefine your research boundaries and strengthen your daily sequencing capability in medical and scientific research fields.

Read Capacity icon
Reads per Run

FCS: 550M / FCL: 1800M

Samples icon
Samples

4 WGS for FCL

read lengths icon
Read Lengths

SE35*, SE50, SE100, PE50*, PE100, PE150, SE400

Specifications

Explore the core capabilities and technical details.

Applications

Whole-Genome

Gene Expression

Targeted Analysis

Metagenomics

Identification

Population Studies

Transcriptome

Methylation Analysis

Multiomics

Instrument Specifications
Performance Parameters
Product Numbers
Resources
trade in video guide

Your Data Security is Our Top Priority

All our sequencing platforms can work as standalone systems from sample to result without any network connection, eliminating the risk of data breaches and ensuring complete data security.

The

DNBSEQ-G400

Advantage

DNBSEQ-G400

Your Day-to-Day Sequencing Solution

CE-IVD

RUO

DNBSEQ-G400 is a versatile benchtop sequencer designed for medium to large genomics projects. Supporting multiple read lengths and sequencing modes, it offers high throughput, accuracy, and flexibility for applications including cancer detection, transcriptomics, and whole genome sequencing. Based on MGI's proprietary DNBSEQ™ Technology, DNBSEQ-G400 supports multi-sequencing modes with increased accuracy, decreased duplicates and reduced index hopping.

Redefine your research boundaries and strengthen your daily sequencing capability in medical and scientific research fields.

A picture of the DNBSEQ-G400 Sequencer from MGI-Tech
Read Capacity icon
Reads per Run

FCS: 550M / FCL: 1800M

Samples icon
Samples

4 WGS for FCL

read lengths icon
Read Lengths

SE35*, SE50, SE100, PE50*, PE100, PE150, SE400

Specifications

Explore the core capabilities and technical details.

Applications

Whole-Genome

Gene Expression

Targeted Analysis

Metagenomics

Identification

Population Studies

Transcriptome

Methylation Analysis

Multiomics

Instrument Specifications
Performance Parameters
Product Numbers
Resources
trade in video guide

Your Data Security is Our Top Priority

All our sequencing platforms can work as standalone systems from sample to result without any network connection, eliminating the risk of data breaches and ensuring complete data security.

The

DNBSEQ-G400

Advantage

DNBSEQ-G400

Your Day-to-Day Sequencing Solution

CE-IVD

RUO

DNBSEQ-G400 is a versatile benchtop sequencer designed for medium to large genomics projects. Supporting multiple read lengths and sequencing modes, it offers high throughput, accuracy, and flexibility for applications including cancer detection, transcriptomics, and whole genome sequencing. Based on MGI's proprietary DNBSEQ™ Technology, DNBSEQ-G400 supports multi-sequencing modes with increased accuracy, decreased duplicates and reduced index hopping.

Redefine your research boundaries and strengthen your daily sequencing capability in medical and scientific research fields.

A picture of the DNBSEQ-G400 Sequencer from MGI-Tech
Read Capacity icon
Reads per Run

FCS: 550M / FCL: 1800M

Samples icon
Samples

4 WGS for FCL

read lengths icon
Read Lengths

SE35*, SE50, SE100, PE50*, PE100, PE150, SE400

Specifications

Explore the core capabilities and technical details.

Applications

Whole-Genome

Gene Expression

Targeted Analysis

Metagenomics

Identification

Population Studies

Transcriptome

Methylation Analysis

Multiomics

Instrument Specifications
Performance Parameters
Product Numbers
Resources
trade in video guide

Your Data Security is Our Top Priority

All our sequencing platforms can work as standalone systems from sample to result without any network connection, eliminating the risk of data breaches and ensuring complete data security.

The

DNBSEQ-G400

Advantage

DNBSEQ-G400

Unmatched Efficiency and Integrated Ecosystem

Unmatched Efficiency
Equipped with four independent lanes in the large flow cell, allowing simultaneous sequencing of different samples, maximizing throughput and resource utilization.

Integrated Research Ecosystem
Seamlessly compatible with MGI's automated library preparation systems and bioinformatics tools, enabling comprehensive solutions from sample preparation to data analysis.

DNBSEQ-G400

Flexibility by Innovative DNBSEQ™ Technology

Flexibility by Innovative DNBSEQ™ Technology

Unrivaled Flexibility
Supports various sequencing modes with two flow cell types, accommodating one or two flow cells per run and multiple read lengths for diverse research needs.

Innovative DNBSEQ™ Technology
Combines advanced biochemistry, optics, fluidics, and temperature control, providing precision and reliability in sequencing for a broad range of applications.

Read Lengths

SE50-FCL

PE50-FCL

SE100-FCL

PE100-FCL

PE150-FCL

SE100-FCS

PE100-FCS

PE150-FCS

Reads

500M

500M

500M

500M

500M

100M

100M

100M

Data Output

~25 Gb

~50 Gb

~50 Gb

~100 Gb

~150 Gb

~10 Gb

~20 Gb

~30 Gb

Q30 *

>85%

>85%

>85%

>85%

>80%

>80%

>85%

>80%

Run Time**


~9 hrs

~15 hrs

~13 hrs

~26 hrs

~40 hrs

~10 hrs

~20 hrs

~28 hrs

Explore Applications

Metagenomics ICON
Metagenomics

Discover MGI's metagenomics NGS solutions for in-depth microbial analysis, from sample processing to detailed reports, uncovering hidden pathogens with cutting-edge sequencing technologies.

HIV-1 Drug resistance
HIV-1 NGS solution

MGI's NGS solution enables efficient HIV-1 genotyping and drug resistance monitoring with advanced sequencing techniques for precise results.

TB Drug resistance
Tuberculosis Drug Resistance Profiling

Experience rapid MTB identification, drug resistance, and traceability through sequencing with MGI's advanced tuberculosis detection and analysis solutions.

Explore Applications

Metagenomics ICON
Metagenomics

Discover MGI's metagenomics NGS solutions for in-depth microbial analysis, from sample processing to detailed reports, uncovering hidden pathogens with cutting-edge sequencing technologies.

HIV-1 Drug resistance
HIV-1 NGS solution

MGI's NGS solution enables efficient HIV-1 genotyping and drug resistance monitoring with advanced sequencing techniques for precise results.

TB Drug resistance
Tuberculosis Drug Resistance Profiling

Experience rapid MTB identification, drug resistance, and traceability through sequencing with MGI's advanced tuberculosis detection and analysis solutions.

Explore Applications

Metagenomics ICON
Metagenomics

Discover MGI's metagenomics NGS solutions for in-depth microbial analysis, from sample processing to detailed reports, uncovering hidden pathogens with cutting-edge sequencing technologies.

HIV-1 Drug resistance
HIV-1 NGS solution

MGI's NGS solution enables efficient HIV-1 genotyping and drug resistance monitoring with advanced sequencing techniques for precise results.

TB Drug resistance
Tuberculosis Drug Resistance Profiling

Experience rapid MTB identification, drug resistance, and traceability through sequencing with MGI's advanced tuberculosis detection and analysis solutions.

Explore Applications

Metagenomics ICON
Metagenomics

Discover MGI's metagenomics NGS solutions for in-depth microbial analysis, from sample processing to detailed reports, uncovering hidden pathogens with cutting-edge sequencing technologies.

HIV-1 Drug resistance
HIV-1 NGS solution

MGI's NGS solution enables efficient HIV-1 genotyping and drug resistance monitoring with advanced sequencing techniques for precise results.

TB Drug resistance
Tuberculosis Drug Resistance Profiling

Experience rapid MTB identification, drug resistance, and traceability through sequencing with MGI's advanced tuberculosis detection and analysis solutions.

Schedule a Meeting with Us

Discover the future of high-throughput sequencing. Schedule a consultation to explore the DNBSEQ-G400 for your research needs

Frequently asked questions about DNBSEQ-G400

Whether pooling library
How many inserts are supported?
Can the Illumina PhiX Control v3 library be used as a balancing library?

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I have read and understood MGI’s Privacy Policy, and I consent to the collection and processing of my personal data for handling, responding to my contact, receiving your newsletter as well as promotion and marketing activities.

*For Research Use Only

Not for use in diagnostic procedures (except as specifically noted).

Copyright © 2026 MGI tech GmbH, Ltd. All Rights Reserved.

Join our newsletter to stay up to date on features and releases.

I have read and understood MGI’s Privacy Policy, and I consent to the collection and processing of my personal data for handling, responding to my contact, receiving your newsletter as well as promotion and marketing activities.

*For Research Use Only

Not for use in diagnostic procedures (except as specifically noted).

Copyright © 2026 MGI tech GmbH, Ltd. All Rights Reserved.

Join our newsletter to stay up to date on features and releases.

I have read and understood MGI’s Privacy Policy, and I consent to the collection and processing of my personal data for handling, responding to my contact, receiving your newsletter as well as promotion and marketing activities.

*For Research Use Only

Not for use in diagnostic procedures (except as specifically noted).

Copyright © 2026 MGI tech GmbH, Ltd. All Rights Reserved.